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San Diego has been called “the birthplace of California”. Historically property to the Kumeyaay individuals, it was the 1st web site visited by Europeans on what is now the West Coast of the United States. On landing in San Diego Bay in 1542, Juan Rodríguez Cabrillo claimed the spot for Spain, forming the basis for the settlement of Alta California 200 many years later. The Presidio and Mission San Diego de Alcalá, founded in 1769, formed the 1st European settlement in what is now California. In 1821, San Diego grew to become portion of the newly declared Mexican Empire, which reformed as the Initial Mexican Republic two many years later. California grew to become portion of the United States in 1848 following the Mexican–American War and was admitted to the union as a state in 1850.
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The Jeep has been widely imitated close to the world, including in France by Delahaye and by Hotchkiss et Cie (right after 1954, Hotchkiss produced Jeeps below license from Willys), and in Japan by Mitsubishi Motors and Toyota. The Land Rover was inspired by the Jeep. The utilitarian great looks of the unique Jeep have been hailed by industrial designers and museum curators alike. The Museum of Modern day Artwork described the Jeep as a masterpiece of functionalist style, and has periodically exhibited the Jeep as element of its assortment. Pulitzer Prize-winning war correspondent Ernie Pyle called the jeep, along with the Coleman G.I. Pocket Stove, “the two most essential pieces of noncombat products ever designed.” Jeeps grew to become even more renowned following the war, as they grew to become offered on the surplus market. Some advertisements claimed to offer you “Jeeps nevertheless in the factory crate.” This legend persisted for decades, despite the reality that Jeeps had been never ever shipped from the factory in crates (even though Ford did “knock down” Jeeps for easier shipping, which may possibly have perpetuated the myth).
The Jeepney is a special kind of taxi or bus created in the Philippines. The first Jeepneys had been military-surplus MBs and GPWs, left behind in the war-ravaged country following Planet War II and Filipino independence. Jeepneys had been created from Jeeps by lengthening and widening the rear “tub” of the automobile, allowing them to carry more passengers. More than the many years, Jeepneys have grow to be the most ubiquitous symbol of the contemporary Philippines, even as they have been decorated in more elaborate and flamboyant types by their owners. Most Jeepneys nowadays are scratch-created by neighborhood producers, utilizing different powertrains.
Aside from Jeepneys, backyard assemblers in the Philippines construct replica Jeeps with stainless steel bodies and surplus parts, and are called “proprietor-kind jeeps” (as jeepneys are also called “passenger-kind jeeps”). Jeeps are also employed for Moab jeep tours, Moab jeep rentals, and Jeep firm tours.
In the United States military, the Jeep has been supplanted by a number of vehicles (e.g. Ford’s M151) of which the most recent is the Humvee.
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San Francisco was founded on June 29, 1776, when colonists from Spain established Presidio of San Francisco at the Golden Gate and Mission San Francisco de Asís a number of miles away, all named for St. Francis of Assisi. The California Gold Rush of 1849 brought rapid growth, generating it the greatest city on the West Coast at the time. San Francisco became a consolidated city-county in 1856. San Francisco’s status as the West Coast’s greatest city peaked in between 1870 and 1900, when close to 25% of California’s population resided in the city appropriate. After 3-quarters of the city was destroyed by the 1906 earthquake and fire, San Francisco was quickly rebuilt, hosting the Panama-Pacific Global Exposition 9 years later. In Globe War II, San Francisco was a significant port of embarkation for services members shipping out to the Pacific Theater. It then became the birthplace of the United Nations in 1945. After the war, the confluence of returning servicemen, considerable immigration, liberalizing attitudes, along with the rise of the “hippie” counterculture, the Sexual Revolution, the Peace Movement growing from opposition to United States involvement in the Vietnam War, and other variables led to the Summer season of Love and the gay rights motion, cementing San Francisco as a center of liberal activism in the United States. Politically, the city votes strongly along liberal Democratic Party lines.
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Jeep is a brand of American automobile and division of FCA US LLC (formerly Chrysler Group, LLC), a wholly owned subsidiary of the Italian-American corporation Fiat Chrysler Vehicles. Jeep has been a component of Chrysler because 1987, when Chrysler acquired the Jeep rock sliders brand, along with remaining assets, from its preceding owner American Motors Corporation (AMC).
Jeep’s recent item assortment consists solely of sport utility cars and off-road cars, but has also incorporated pickup trucks and roadsters in the past Jeep bumpers returned to the pickup truck industry in early 2019. Some of Jeep’s vehicles—such as the Grand Cherokee—reach into the luxury SUV section, a industry section the Wagoneer is deemed to have created. Jeep sold 1.four million SUVs globally in 2016, up from 500,000 in 2008, two-thirds of which in North America, and was Fiat-Chrysler’s greatest promoting brand in the U.S. in the course of the 1st half of 2017. In the U.S. alone, more than 2400 dealerships hold franchise rights to promote Jeep-branded cars, and if Jeep have been spun off into a separate organization, it is estimated to be worth amongst $22 and $33.5 billion—slightly far more than all of FCA (US).
Prior to 1940 the term “jeep” had been used as U.S. Army slang for new recruits or cars, but the World War II “jeep” that went into production in 1941 particularly tied the title to this light military 4×4, arguably creating them the oldest 4-wheel drive mass-production cars now acknowledged as SUVs. The Jeep grew to become the major light four-wheel-drive automobile of the United States Army and the Allies in the course of World War II, as properly as the postwar period. The term grew to become frequent globally in the wake of the war. Doug Stewart noted: “The spartan, cramped, and unstintingly functional jeep grew to become the ubiquitous World War II 4-wheeled personification of Yankee ingenuity and cocky, can-do determination.” It is the precursor of subsequent generations of military light utility cars such as the Humvee, and inspired the creation of civilian analogs such as the original Series I Land Rover. Several Jeep variants serving related military and civilian roles have because been developed in other nations.
The Jeep marque has been headquartered in Toledo, Ohio, ever because Willys-Overland launched production of the 1st CJ or Civilian Jeep branded versions there in 1945. Its replacement, the conceptually consistent Jeep Wrangler series, stays in production because 1986. With its strong axles and open prime, the Wrangler has been known as the Jeep off-road accessories model that is as central to the brand’s identity as the rear-engined 911 is to Porsche.
At least two Jeep versions (the CJ-5 and the SJ Wagoneer) loved extraordinary three-decade production runs of a single entire body generation.
In lowercase, the term “jeep” continues to be used as a generic term for cars inspired by the Jeep that are suitable for use on rough terrain.
San Jose is a global city, notable as a center of innovation, for its affluence, Mediterranean climate, and really substantial cost of residing. San Jose’s spot inside the booming substantial tech business, as a cultural, political, and financial center has earned the city the nickname “Capital of Silicon Valley”. San Jose is a single of the wealthiest key cities in the United States and the globe, and has the third highest GDP per capita in the globe (soon after Zürich, Switzerland and Oslo, Norway), according to the Brookings Institution. The San Jose Metropolitan Region has the most millionaires and the most billionaires in the United States per capita. With a median home cost of $one,085,000, San Jose has the most pricey housing market place in the country and the fifth most pricey housing market place in the globe, according to the 2017 Demographia International Housing Affordability Survey. Key global tech firms including Cisco Systems, eBay, Adobe Systems, PayPal, Broadcom, Samsung, Acer, Hewlett Packard Enterprise, and Western Digital maintain their headquarters in San Jose, in the center of Silicon Valley.
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Before the arrival of the Spanish, the location close to San Jose was inhabited by the Tamien nation of the Ohlone peoples of California. San Jose was founded on November 29, 1777, as the Pueblo de San José de Guadalupe, the 1st city founded in the Californias. It then grew to become a component of Mexico in 1821 soon after the Mexican War of Independence. Following the American Conquest of California for the duration of the Mexican–American War, the territory was ceded to the United States in 1848. Following California achieved statehood two many years later on, San Jose grew to become the state’s 1st capital. Following World War II, San Jose skilled an financial boom, with a speedy population development and aggressive annexation of close by cities and communities carried out in the 1950s and 1960s. The speedy development of the substantial-engineering and electronics industries more accelerated the transition from an agricultural center to an urbanized metropolitan location. Benefits of the 1990 U.S. Census indicated that San Jose had officially surpassed San Francisco as the most populous city in Northern California. By the 1990s, San Jose and the rest of Silicon Valley had turn out to be the global center for the substantial tech and internet industries, making it California’s fastest-expanding economic climate.
Stem cells are cells with the possible to produce into numerous different kinds of cells in the entire body
There are 3 known available sources of autologous grownup stem cells in humans: bone marrow, adipose tissue, and blood. Stem cells can also be taken from umbilical cord blood just soon after birth. Of all stem cell treatment types, autologous harvesting involves the least danger.
Adult stem cells are frequently utilised in a variety of health care therapies (e.g., bone marrow transplantation). Stem cells can now be artificially grown and transformed (differentiated) into specialized cell types with qualities consistent with cells of a variety of tissues this kind of as muscles or nerves. Embryonic cell lines and autologous embryonic stem cells created by way of somatic cell nuclear transfer or dedifferentiation have also been proposed as promising candidates for long term therapies. Analysis into stem cells grew out of findings by Ernest A. McCulloch and James E. Until at the University of Toronto in the 1960s.
Stem cells are cells with the potential to produce into a lot of different types of cells in the body. They serve as a restore program for the body. There are two major types of stem cells: embryonic stem cells and grownup stem cells.
Stem cells are different from other cells in the body in 3 ways:
- They can divide and renew themselves more than a long time
- They are unspecialized, so they can’t do distinct functions in the body
- They have the potential to turn into specialized cells, this kind of as muscle cells, blood cells, and brain cells
Physicians and scientists are thrilled about stem cells since they could aid in a lot of different areas of overall health and health care research. Learning stem cells could aid clarify how critical conditions this kind of as birth defects and cancer come about. Stem cells could a single day be utilised to make cells and tissues for treatment of a lot of diseases. Examples consist of Parkinson’s disease, Alzheimer’s disease, spinal cord damage, heart disease, diabetes, and arthritis.
How can stem cells treat disease?
When most individuals consider about about stem cells treating disease they consider of a stem cell transplant.
In a stem cell transplant, embryonic stem cells are initial specialized into the essential grownup cell sort. Then, those mature cells exchange tissue that is damaged by disease or damage. This sort of therapy could be utilised to:
- exchange neurons damaged by spinal cord damage, stroke, Alzheimer’s disease, Parkinson’s disease or other neurological issues
- make insulin that could treat individuals with diabetes and heart muscle cells that could restore damage soon after a heart attack or
- exchange almost any tissue or organ that is injured or diseased.
But embryonic stem cell-based therapies can do a lot more.
- Learning how stem cells produce into heart muscle cells could offer clues about how we could induce heart muscle to restore itself soon after a heart attack.
- The cells could be utilised to research disease, determine new drugs, or screen drugs for toxic side effects.
Any of these would have a considerable influence on human overall health without having transplanting a single cell.
In theory, there is no restrict to the types of diseases that could be taken care of with stem cell research. Offered that researchers could be able to research all cell types via embryonic stem cells, they have the potential to make breakthroughs in any disease.
CIRM has created disease pages for a lot of of the major diseases currently being targeted by stem cell scientists. You can locate those disease pages here.
You can also sort our total list of CIRM awards to see what we have funded in different disease areas.
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Seattle is located on an isthmus concerning Puget Sound (an inlet of the Pacific Ocean) and Lake Washington, about a hundred miles (160 km) south of the Canada–United States border. A important gateway for trade with Asia, Seattle is the fourth-largest port in North America in terms of container dealing with as of 2015.
The Seattle spot was inhabited by Native Americans for at least 4,000 years just before the initial everlasting European settlers. Arthur A. Denny and his group of vacationers, subsequently recognized as the Denny Get together, arrived from Illinois by means of Portland, Oregon, on the schooner Precise at Alki Point on November 13, 1851. The settlement was moved to the eastern shore of Elliott Bay and named “Seattle” in 1852, in honor of Chief Si’ahl of the area Duwamish and Suquamish tribes. Right now, Seattle has high populations of Native, Scandinavian, African, and Asian Americans, as well as a thriving LGBT community that ranks 6th in the United States for population.
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Logging was Seattle’s initial important field, but by the late 19th century, the city had turn into a business and shipbuilding center as a gateway to Alaska all through the Klondike Gold Rush. Growth soon after Planet War II was partially due to the area Boeing corporation, which established Seattle as a center for aircraft manufacturing. The Seattle spot created into a technologies center from the 1980s onwards with businesses like Microsoft turning into established in the region Microsoft founder Bill Gates is a Seattleite by birth. Online retailer Amazon was founded in Seattle in 1994, and important airline Alaska Airlines is based mostly in SeaTac, Washington, serving Seattle’s global airport, Seattle–Tacoma Worldwide Airport. The stream of new software program, biotechnology, and Online businesses led to an economic revival, which elevated the city’s population by just about 50,000 concerning 1990 and 2000. Owing largely to its quickly escalating population in the 21st century, Seattle and the state of Washington have some of the highest minimal wages in the country, at $15 per hour for smaller enterprises and $16 for the city’s largest employers.
Not too long ago, the South Bend population has started out to expand for the 1st time in virtually fifty many years
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The area was originally settled in the early 19th century by fur traders and was established as a city in 1865. The St. Joseph River shaped South Bend’s economic climate by way of the mid-20th century. River accessibility assisted hefty industrial improvement such as that of the Studebaker Corporation, the Oliver Chilled Plow Business, and other massive firms.
The population of South Bend declined soon after 1960, when it had a peak population of 132,445. This was chiefly due to migration to suburban regions as nicely as the demise of Studebaker and other hefty business. These days, the biggest industries in South Bend are health care, education, tiny organization, and tourism. Remaining massive firms include Crowe Horwath, Honeywell, and AM Standard.
Recently, the city population has started out to increase for the initial time in almost fifty years. The old Studebaker plant and surrounding area, now known as Ignition Park, is currently being redeveloped as a engineering center to appeal to new business.[
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Spartanburg is the most populous city in and the seat of Spartanburg County, South Carolina, United States, and the 12th-largest city by population in the state. The city of Spartanburg has a municipal population of 37,013, and Spartanburg County has an urban population of 180,786 as of the 2010 census. For a time, the Workplace of Management and Budget grouped Spartanburg and Union Counties collectively as the “Spartanburg Metropolitan Statistical Spot”, but as of 2018 the OMB defines only Spartanburg County as the Spartanburg MSA.
Spartanburg is the 2nd-largest city in the greater Greenville–Spartanburg–Anderson Combined Statistical Spot, which has a population of one,385,045 as of 2014. It is component of a ten-county region of northwestern South Carolina identified as “The Upstate,” and is located 98 miles (158 km) northwest of Columbia, 80 miles (130 km) west of Charlotte, North Carolina, and about 190 miles (310 km) northeast of Atlanta, Georgia.
Spartanburg is the residence of Wofford University and the website of headquarters for Denny’s. Spartanburg is also residence of the BMW Spartanburg factory.
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